Shigenobu Shibata Selected Research

Chronobiology Disorders (Circadian Rhythm Disorder)

12/2022	Polygalae Radix shortens the circadian period through activation of the CaMKII pathway.
1/2017	Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts.
3/2012	2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2::Luciferase knockin mice: lack of dependence on anesthetic activity.
10/2005	[A role of nociceptin in the entrainment mechanism of the biological clock].

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Shigenobu Shibata Research Topics

Disease

5	Hypersensitivity (Allergy) 11/2017 - 08/2013
4	Chronobiology Disorders (Circadian Rhythm Disorder) 12/2022 - 10/2005
3	Body Weight (Weight, Body) 02/2022 - 09/2011
3	Inflammation (Inflammations) 01/2020 - 12/2015
3	Anaphylaxis (Anaphylactic Shock) 04/2016 - 04/2011
2	Hypertension (High Blood Pressure) 01/2022 - 01/2020
2	Hypertrophy 01/2021 - 12/2019
2	Neoplasms (Cancer) 01/2020 - 01/2017
2	Type 2 Diabetes Mellitus (MODY) 11/2019 - 01/2019
2	Hypoxia (Hypoxemia) 01/2018 - 10/2015
2	Mental Disorders (Mental Disorder) 10/2017 - 02/2010
2	Fetal Growth Retardation (Intrauterine Growth Retardation) 10/2015 - 05/2010
2	Shock 01/2010 - 05/2003
1	Constipation 01/2021
1	Sarcopenia 01/2021
1	Fibrosis (Cirrhosis) 01/2020
1	Chronic Disease (Chronic Diseases) 11/2019
1	Chronic Renal Insufficiency 01/2019
1	Muscular Atrophy (Muscle Atrophy) 01/2017
1	Jet Lag Syndrome 01/2017
1	Obesity 01/2017
1	Allergic Rhinitis 04/2016
1	Dermatitis 12/2015
1	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2015
1	Fetal Hypoxia 10/2015
1	Pre-Eclampsia (Preeclampsia) 10/2015
1	Food Hypersensitivity (Food Allergy) 09/2015
1	Fatty Liver 01/2014
1	Colitis 01/2014
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 09/2011
1	Schizophrenia (Dementia Praecox) 05/2010
1	AIDS-Related Complex (ARC) 02/2010
1	Sepsis (Septicemia) 01/2010

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2016
3	Messenger RNA (mRNA)IBA 02/2022 - 05/2003
3	LipidsIBA 02/2022 - 04/2009
3	CytokinesIBA 01/2018 - 01/2014
3	GlucocorticoidsIBA 01/2018 - 02/2010
3	Immunoglobulin E (IgE)IBA 04/2016 - 01/2014
3	Dexamethasone (Maxidex)FDA LinkGeneric 04/2016 - 07/2007
2	Dietary ProteinsIBA 01/2021 - 12/2019
2	Glucose (Dextrose)FDA LinkGeneric 05/2020 - 08/2007
2	Histamine (Histamine Dihydrochloride)FDA Link 11/2017 - 01/2014
2	CorticosteroneIBA 04/2016 - 04/2011
2	AllergensIBA 04/2016 - 01/2014
2	Insulin (Novolin)FDA Link 09/2011 - 08/2007
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 12/2022
1	Triglycerides (Triacylglycerol)IBA 02/2022
1	Volatile Fatty AcidsIBA 02/2022
1	PotassiumIBA 01/2022
1	SodiumIBA 01/2022
1	Magnesium Oxide (Magnesia)FDA Link 01/2021
1	Dietary Fiber FDA Link 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	Branched-Chain Amino AcidsIBA 01/2021
1	Dopamine (Intropin)FDA LinkGeneric 01/2020
1	Adenine FDA LinkGeneric 01/2020
1	gamma-oryzanolIBA 01/2020
1	Caseins (Casein)FDA Link 01/2020
1	Soybean Proteins (Soy Protein)IBA 12/2019
1	salicylhydroxamic acid (SHAM)IBA 12/2019
1	Kruppel-Like Transcription Factors (Kruppel-Like Factors)IBA 10/2017
1	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 01/2017
1	FlavonesIBA 01/2017
1	FlavonoidsIBA 01/2017
1	PF-670462IBA 04/2016
1	IgE Receptors (Fc epsilon RI)IBA 04/2016
1	Casein Kinases (Casein Kinase)IBA 04/2016
1	Interleukin-23 (Interleukin 23)IBA 12/2015
1	Imiquimod (Aldara)FDA LinkGeneric 12/2015
1	Toll-Like Receptor 7IBA 12/2015
1	LigandsIBA 12/2015
1	Angiogenic ProteinsIBA 10/2015
1	Oxygen (Dioxygen)IBA 10/2015
1	Hemoglobins (Hemoglobin)IBA 10/2015
1	OvalbuminIBA 09/2015
1	AntigensIBA 09/2015
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2014
1	AcetylcholinesteraseIBA 01/2014
1	Cholinesterases (Cholinesterase)IBA 01/2014
1	ChemokinesIBA 01/2014
1	very low density lipoprotein triglycerideIBA 01/2014
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2014
1	OccludinIBA 01/2014
1	Claudin-1IBA 01/2014
1	Tight Junction ProteinsIBA 01/2014
1	Dextrans (Dextran)FDA Link 01/2014
1	EndotoxinsIBA 08/2013
1	Anesthetics (Anesthetic Agents)IBA 03/2012
1	General AnestheticsIBA 03/2012
1	LeptinIBA 09/2011
1	gingerolIBA 09/2011
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 05/2010
1	Nerve Growth Factors (Neurotrophins)IBA 05/2010
1	Dimenhydrinate (DMH)FDA LinkGeneric 02/2010
1	LipopolysaccharidesIBA 01/2010

Therapy/Procedure

2	Therapeutics 12/2022 - 10/2015
1	Diet Therapy (Therapy, Diet) 11/2019
1	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 01/2019
1	Adrenalectomy 04/2011